CFTR Class Polymorphism group Genotype Ethnicity Total OR 95%CI Caucasian Non-Caucasian MI/MI* 315 bases deletion -/- 18 6 24 0.052 0.002 – 0.382 -/+ 44 1 45 7.694 1.058 – 183.5 +/+ 16 0 16 - - Total 78 7 85     Total* 315 bases deletion -/- 43 8 51 0.154 0.032 – 0.592 -/+ 76 3 79 2.76 0.725 – 13.29 +/+ 30 0 30 - - Total 149 11 160     CFTR Class Polymorphism group Genotype Age Total OR 95%CI < 154 months ≥ 154 months NMI/NMI* 315 bases deletion -/- 4 10 24 1.503 0.298 – 7.301 -/+ 0 15 15 - - +/+ 5 4 9 7.257 1.321 – 44.83 Total 9 29 38     Total* 315 bases deletion -/- 22 29 51 0.826 0.423 – 1.603 -/+ 37 42 79 0.819 0.438 – 1.528 +/+ 20 10 30 2.394 1.046 – 5.721 Total 79 81 160     CFTR Class Polymorphism group Genotype Ethnicity Total OR 95%CI Caucasian Non-Caucasian MI/MI# 315 bases deletion clustered -/- 18 6 24 0.052 0.002 – 0.382 -/+ and +/+ 60 1 61 1 - Total 78 7 85     Total# 315 bases deletion clustered -/- 43 8 51 0.154 0.032 – 0.592 -/+ and +/+ 106 3 109 1 - Total 149 11 160     CFTR Class Polymorphism group Genotype Ethnicity Total OR 95%CI Caucasian Non-Caucasian MI/MI* Haplotype 0 12 5 17 0.076 0.009 – 0.432 1 37 1 38 5.327 0.742 – 128.5 2 15 0 15 - - 3 6 1 7 0.505 0.059 – 13.42 4 8 0 8 - - Total 78 7 85

Table 3: Association of 315 bases deletion (variation #11592, also known as rs35417183) in ADIPOR2 gene with thecategorical variables of cystic fibrosis patients ADIPOR2- Adiponectin Receptor 2; CFTR- Cystic Fibrosis Transmembrane Regulator; OR- Odds ratio; Ci- Confidential Interval; MI- CFTR Mutation Class I, II or III; MNI, no identified CFTR mutation or CFTR mutation Class IV, V or VI; +, represents the polymorphism presence; 0, only wild-type alleles; 1, insertion of 134 bases with wildtype + 315 bases deletion with one deleted allele; 2, insertion of 134 bases with wild-type + 315 bases deletion with two deleted alleles; 3, insertion of 134 bases with one inserted allele + 315 bases deletion with wild alleles; 4, insertion of 134 bases with one inserted allele + 315 bases deletion with one/two deleted alleles. * Statistical analysis performed by χ2 test; # Statistical analysis performed by Fisher’s Exact Test. The positive values are in bold. The odds ratios were performed considering the best approach using the epi info software, in this case, the Mid P test was considered.