Ethnicity Country Author Year                   Cases/Controls for  MTRR A66G Ref          N AA AG GG   Caucasian USA Hobbs et al. 2000 145/139 26/39 64/68 55/32 14 Ireland O’Leary et al. 2002 48/192 1/35 23/101 24/56 25 USA Chango et al. 2005 119/120 5/6 66/72 48/42 36 Italy Scala et al. 2006 94/264 28/69 46/131 19/57 27 Brazilian Brazil Da Silva et al. 2006 154/158 37/45 92/87 25/26 37 Brazil Brandalize et al. 2010 239/197 42/42 137/111 60/44 31 Asian India Ambreen et al 2014 60/62 2/1 48/59 10/2

Table 2: Characteristics of studies included in the meta- analysis for MTRR A66G gene polymorphism [14,16,21,24-26,30].