Figure 1: A simplified scheme of regulatory cross-talk between α1D-adrenergic receptor (α1D-AR) and Transient Receptor Potential Vanilloid 1 (TRPV1) that includes multiple parallel and converging downstream signal transduction pathways. DAG: diacylglycerol; IP3: inositol 1,4,5-trisphosphate; IP3R: IP3 receptor; MAPK: mitogen activated protein kinases; NE: norepinephrine; PI3K: phosphatidylinositol-4,5-bisphosphate 3-kinase; PIP2: phosphatidylinositol 4,5-bisphosphate; PKC: protein kinase C; PLC: phospholipase C.