Classification

Coagulation factor level
(VIII:C or IX:C)

Clinical phenotype

Severe

<0·01 IU/mL
(<1% of normal activity)

Spontaneous soft tissue and musculoskeletal bleeding

Moderate

0·01–0·05 IU/mL
(1–5% of normal activity)

Bleeding into joints and
 muscles after minor
injuries or after surgical intervention

Mild

>0·05–0·40 IU/mL
(5–40% of normal activity)

Post-operative and post-traumatic bleeding only

Table 1: Phenotypic classification of hemophilia and its clinical features (White et al., 2001)[14].