Category Determinants
Genetic factors Type of FVIII/FIX mutation
  Functional polymorphisms in genes encoding cytokines, their receptors, immune-regulatory molecules that participate in antigen processing and T-cell and B-cell function.
Treatment-related factors Age at first factor replacement
  Type of factor concentrates used and mode of administration
  Frequency and dose of administration
Environmental factors Race and ethnicity of patient
  Challenges to Immune system (Infections, allergy etc.)
Table 3: Possible determinants of inhibitor development in patients with hemophilia.