| Category |
Determinants |
| Genetic factors |
Type of FVIII/FIX mutation |
| |
Functional polymorphisms in genes encoding cytokines, their receptors, immune-regulatory molecules that participate in antigen processing and T-cell and B-cell function. |
| Treatment-related factors |
Age at first factor replacement |
| |
Type of factor concentrates used and mode of administration |
| |
Frequency and dose of administration |
| Environmental factors |
Race and ethnicity of patient |
| |
Challenges to Immune system (Infections, allergy etc.) |
