Figure 5: Allosteric CXCR1/2 inhibition has no significant effect on body weight, while methylprednisolone (MP) treatment reduces the weight in immunization-induced EBA during the 4-week observation period. Body weight of mice with immunization-induced EBA was recorded at the beginning and at the end of the 4-week treatment period. While untreated mice with immunization-induced EBA gained weight (n=7), immunized mice treated with MP (20 mg/kg/day, n=6) showed a significant weight loss and DF2156A-treated mice showed no significant difference in weight compared to untreated controls (n=7, 15 mg/kg and n=6, 30 mg/kg)). Data is presented as mean ± SEM. *indicates statistical difference in comparison to control mice (ANOVA followed by Bonferroni t-test for multiple comparisons versus mice with untreated EBA).