Position(s) in protease
Protease inhibitors Critical substitutions Additional substitutions
Saquinavir 48, 90 10, 36, 63, 71
Ritonavir 82, 84 20, 36, 46, 54, 63, 71, 90
Indinavir 46, 82 10, 20, 24, 32, 54, 63, 71, 84, 90
Nelfinavir 30 46, 63, 71, 88, 90
Amprenavir 50 10, 46, 47
Table 3: The HIV-1 mutations that confer resistance to the main protease inhibitors. [16-21].