Toxic signs No. of the sign Vomiting or nausea 29 Anorexia  16 Lip erosion     12 Stomatitis        34 Pharyngeal pain      27 Stomach pain 11 Diarrhea      5 Gingiva hemorrhage 5 Leukopenia<4,000  22 Headache       4 Skin rash          3 No toxicity in 23 cases

Table 1: Systemic toxicity of MTX in the prophylactic chemotherapy.