Figure 3: MicroRNAs are secreted into the circulation and are biomarkers for various diseases. MiRNAs are secreted by various lipid containing vesicles including exosomes, microvesicles, and apoptotic bodies and can be found outside of vesicles but beyond to RNA binding proteins (left) specific miRNA that are highlighted as biomarkers are indicated as well as the tissue of origin, potentially where disease is occurring i.e., adipose tissue, liver, heart and aorta (right) [174].