WCC CRP Combination test   Acute Comp Either Acute Comp Either Acute Comp Either Sensitivity (95% CI) 0.66 (0.59-0.72) 0.21 (0.16-0.25) 0.89 (0.85-0.92) 0.59 (0.56-0.62) 0.20 (0.18-0.21) 0.79 (0.76-0.83) 0.83 (0.76-0.90) 0.70 (0.59-0.75) 0.79 (0.73-0.84) Specificity (95% CI) 0.47 (0.42-0.52) 0.89 (0.85-0.923) 0.42 (0.35-0.49) 0.36 (0.27-0.46) 0.95 (0.89-0.98) 0.35 (0.27-0.44) 0.53 (0.42-0.62) 0.93 (0.80-0.99) 0.68 (0.59-0.75) X2 (Yates) 4.57 4.95 37.17 0.46 9.47 6.11 2.93 9.97 39.24 p value 0.03 0.03 <0.0001 0.50 <0.01 0.01 0.09 <0.01 <0.0001

Table 4: Summary of contingency table outcomes for WCC and CRP. WCC was found to be a statistically significant indicator of acute disease presence, whilst CRP was not. Whilst not specific tests, both reflected a high sensitivity for presence of the disease with the WCC being more sensitive than a rise in CRP levels. Combination testing, whereby at least one of the variables was positive, increased sensitivity and specificity in both groups. Chi-squared (Χ2) analysis indicated the WCC to be statistically significant