Figure 1: A two-state dynamical vs a two-state stochastic model. Thegraphs summarize the statistical analysis of a typical randomized clinical trialbased on hypothetical data. The left panel illustrates conventional Kaplan-Meier curves for which the hazard ratio (HR) and 95% log normal confidenceinterval (CI) are computed using Cox proportional hazards regression.The black line is for the control group and the grey line is for the treatmentgroup. The right panel illustrates analogous curves derived from a dynamicalanalysis of the same data. The points represent 1000 random resamplesof the log-normally distributed rate constants and exponentially distributedtime-to-event data. The black points represent the control group and the greypoints represent the treatment group. The hazard ratio and 95% confidenceinterval derived from these data are similar to those using Cox regression.