Control Group Treatment Group   Transition Events Pts Days k±SEM Events Pts Days k±SEM ↓k1 CAD→UA 165 1000 90 0.0020 ±  0.0002 86 1000 90 0.0010±0.0001 UA→MI 163 165 45 0.0981 ±0.0156 85 86 45 0.0990±0.0221       ↓k2 CAD→UA 165 1000 90 0.0020 ± 0.0002 165 1000 90 0.0020±0.0002 UA→MI 163 165 45 0.0981 ± 0.0156 147 165 45 0.0492±0.0049

Pts=Patients, k=kinetic rate constant (−ln[1−Events/Pts]/Days), SEM=standard error of the mean, CAD=coronary artery disease, UA=unstable angina, MI= myocardial infarction, CAD→UA=transition from the initial state (CAD) to the intermediate state (UA), UA→MI=transition from the intermediate state (UA) to the terminal state (MI), ↓k1=reduced initial transition rate, ↓k2=reduced subsequent transition rate. The numbers in boldface represent 50% reductions in the post-treatment rate constants.

Table 1: Hypothetical Assessment of Revascularization Interventions (HARI)