Intermediate State Terminal State
    Stochastic Model Dynamical Model Stochastic Model Dynamical Model
  HR 0.32 0.50 0.57 1.00
k1 95% CI 0.17-0.61 0.38-0.65 0.43-0.75 0.59-1.73
  p 0.001 0.000 0.000 0.973
     
  HR 1.30 1.00 0.85 0.50
k2 95% CI 0.87-1.93 0.81-1.24 0.67-1.09 0.35-0.73
  p 0.198 1.000 0.208 0.000
HR=hazard ratio, CI=confidence interval, p=p-value, ↓k1=reduced initial transition rate, ↓k2=reduced subsequent transition rate. Values for the stochastic model are based
on Cox regression; values for the dynamical model are based on a z test of the rate constants
Table 2: Stochastic and dynamical analysis of HARI