Figure 5: SPARC-NP is able to detect prostate cancer lung metastases. FMT-CT fusion, illustrating in vivo detection of tumor in the lung. A. The left panel shows fluorescence data from FMT imaging of SPARC-targeted agent in mouse with metastatic tumor in the lung. Right panel is a maximum intensity projection image of the CT and FMT data sets. B. H&E staining of excised lungs corroborates in vivo imaging results. Top panel illustrates normal lung architecture. Bottom panel shows deposition of tumor cells (left) next to normal lung tissue (right). Scalebars are 1mm