MATERIAL |
METHOD |
CONCENTRATON |
RESULTS |
AUTHOR |
|
|
|
|
|
Polyamidoamine-MWCNT-plasmid DNA |
Hela cells |
50 µg/ml |
Decreased cytotoxicity
by 38% |
[153] |
MWCNT-COOH;MWCNT-NH2 |
Human astrocyte D384
And lung A549 cells |
1 µg/ml |
High solubility and dispersibility,
Reduced toxicity |
[154] |
MWCNT-COOH,
MWCNT- PVA
MWCNT-Apatite
(PVA: Poly Vinyl alcohol) |
MG-63 human osteoblastic cells |
|
MWCNT-Apatite shows higher cell viability than MWCNT-COOH and MWCNT-PVA
|
[155] |
pEGFPplasmid DNA-SWCNT |
Mouse B-cells cortical neurons |
0.1pM/10mL |
Only 10% non-viable cells |
[156] |
Glycopolymer-SWCNT-plasmid
(pEGFP) |
HeLa cells |
0.1 mg/ml |
No toxicity |
[157] |
|
|
|
|
|
(SWCNT-NH3+;MWCNT- NH3+)lysine
Functionalized with plasmid DNA |
A549 cells |
150 µg/ml |
Good gene delivery vector |
[158] |
|
|
|
|
|
Plasmid DNA-SWCNT and
Plasmid DNA-MWCNT |
HeLa cell line |
10mg/ml |
Exhibit low toxicity, improved gene expression up to 10 folds. |
[22] |
FITC-SWCT and
biotin-SA-SWCNT |
HL60,3T3,Chinese hamster ovary cell |
0.05mg/ml |
Both the f-CNTs were internalized inside the cells without toxicity by endocytosis. |
[63] |
f-CNT prepared by 1,3
cycloaddition and oxidation/
amidation |
B&T lymphocytes and macropghages |
1-10µg/ml |
f-CNTs were uptaken by cells,
highly soluble and preserved the activity of immunoregulatory cells |
[159] |
SWCNT-phenyl-SO3H,
SWCNT-phenyl- SO3Na,
SWCNT-phenyl-COOH,
SWCNT in pluronic F108 |
Cultured human
Dermal fibroblast |
3µg/ml-30µg/ml |
Reduced in toxicity observed with
Increased of degree of functionalization. f-CNT were less toxic than surfactant stabilized SWCNT. |
[160] |
|
|
|
|
|
Pluronic F127(PF127) surfactant
coated MWCT |
Mouse cerebral cortex,
Cultured human blastoma cells |
0.01%,
5-10mµg/ml |
No degeneration of neurons, no
Induction of apoptosis,
Presence of MWCNT reduced toxicity of PF127 |
[52, 161, 162]
|
MWCNT- NH2 |
Fibroblast L929 cell line |
1-50 µg/ml |
Non-toxic but reduced cell growth observed |
[163] |
|
|
|
|
|
NH2-MWCNT-DNA |
HUVEC cell & A375(human melanoma cell line) |
60µg/ml |
No cell toxicity |
[164] |
SWCNT-AHA
(AHA: 6-aminohexanoic acid) |
HEK cells(human epidermal keratinocytes) |
0.00000005-0.05mg/ml |
Maintains cell viability |
[165] |
PEI-MWCNT-DNA |
HEpG2 and COS7 cells |
1mg/ml |
Low toxicity, improved gene expression up to 10 folds. |
[166] |
Non covalently functionalized with PEG
(PEG-SWCNT)
Oxidized, covalently functionalized PEG
(PEG- O- SWCNT)
(PEG: Poly ethylene glycol) |
mice |
100µl |
PEG-SWCNT less toxic than PEG O SWCNT |
[167] |
|
|
|
|
|
MWCNT-COOH,
MWCNT-Amide and
MWCNT- Benezimidazole |
Fibroblast cells |
|
Functionalized CNTs show more than 50 % cell viability |
[168] |
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