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Figure 2: In vitro drug release of lomustine as function of component variables. (A) Release of lomustine, batches APL and APL1, and APL2 as a function of PLA concentration. (B) Release of lomustine, batches APL, APL3, and APL4 as a function of lomustine concentration, (C) Release of lomustine, batches APL and APL5 as a function of aqueous phase (PVA solution) amount, (D) Release of lomustine, batches APL, APL6-7 as a function of PVA solution concentration, (E) Release of lomustine batches APL, APL8 as a function of PVA incorporation mode (F) Release of lomustine, batches APL10-12 as a function of co-solvent ethanol addition. (G) Release of lomustine, batches APL, APL13-14 as a function of organic solvent evaporation condition, (H) Release of lomustine, batches APL, APL15-19 as a function of homogenization speed and time. |