Figure 1: Design of the NANOM FIM trial. Panel schematically represents the main design and methods of the trial. Frame (I) shows the appearance of the advanced culprit lesion before the intervention. Frame (II) depicts implantation of metal nanoparticles (NP) with bioengineered on-artery patch grown with stem cells pre-incubated in the medium with NP. Frame (III) demonstrates a detonation of NPs inside the lesion with transcatheter near-infrared (NIR) high energy laser. Frame (IV) documents a melting and shrinkage of atheroma with reduction of plaque burden and late lumen enlargement. Frame (V) shows adaptive artery remodeling with envisioned atheroregression below Glagov threshold. This technique causes late lumen enlargement, plaque reduction with integration of bioengineered onartery scaffold to the superficial envelope of artery. Frames (VI-IX) show an alternative scenario of the NP delivery. Frame (VI) shows the phase of the NP transfer to the lesion with intravascular catheter and stem cells or microbubbles. Yellow arrows show distribution of NP in the lesion. Yellow dots designate NP. Frame (VII) demonstrates a phase of the NP detonation under NIR laser irradiation with out-body high-energy NIR device. The functionalized gold NP that forms a cluster around a target molecule, and when excited with a short laser pulse, act as a heat source, thus generating an intracellular photothermal vapor bubble. Optical and mechanical effects of the bubble can be controlled through the laser parameters to tune the bubble to diagnostic or therapeutic task. Red multi-pointed stars depict a detonation of nanoparticles. A laser irradiation showed as a rose light beam. Frame (VIII) documents a melting and shrinkage of atheroma with reduction of plaque burden and late lumen enlargement. Green arrows show the shrinkage of lesion. Frame (IX) depicts adaptive artery remodeling with envisioned atheroregression below Glagov threshold. Frames (X and XI) depict stenting of the vessel with implantation (frame X) of everolimus-eluting stent with further re-endothelialization (frame XI).