Cluster Assignment Cluster Number 1 2 3 4 P53 (p) 1 1 4 (66%) - PTPN11-SH2 (pt) 3 3 (50%) - - Src-SH2 (s) - 3 1 1 (20%) CDK2 (c) 2 (33%) 1 3 - A = Src – SH2* 1 2 - 3 (50%) B = cdk2 2 (40%) 2 - 1 C = p53 4 - 1(20%) - D = PTPN11-SH2 1 2 (20%) 2 - E = PTPN11-SH2 - 4 (100%) - - F = PTPN11-SH2 2 4 (50) 1 1

Table 7: Cluster assignment for each known protein sample on a specimen of 56 spectra. Statistics are based on the SpADS results coupled with K Means clustering given in figure 10. In bold assignment of clusters by human interpretation of cluster results. Highlited with * striking recognition.