Figure 1: Schematic representation of the effect of loading on internalization and the cytotoxicity of SMA-Dox micelles with high loading (blue) and low loading (red) against MDA-MB 231 overexpressing caveolin-1 and DU145 cells that under-express caveolin-1. In cells will low caveolin-1 expression, the cytotoxicity is heavily dependent on micelle loading. Conversely, in cells with high expression of caveolin-1, Such as MDA-MB-231 cells, the cytotoxicity is similar across the different loadings as micelle uptake is nonrate limiting.