The reduction in stress generation is reported as the percentage relaxation from a phenylephrine (30 μM for uterine/mesenteric arteries and 10 μM for aorta) prestimulation stress level in response to cumulative additions of a Rho kinase inhibitor (HA1077). All responses were assessed by wire myography, 24 hours following intratracheal instillation of 100 μg/kg of (S)-MWCNTs or 10% surfactant from 17 - 19 days pregnant (A, C and E) and non-pregnant female (B, D and F) Sprague Dawley rats. Panels A and B: main uterine artery; C and D: first order mesenteric artery; E and F: thoracic aorta. # indicates p < 0.05 compared to naïve using repeated measures ANOVA (n = 4 - 6). The p values were derived following the comparison of each concentration response curve across treatment groups using a regression analysis by examining the best-fit values.
