Percentage of duration of visits (%)
Control
1.25 mg/kg
2.5 mg/kg
5 mg/kg
Novel arm
44 ± 5.5
30 ± 4.2*
16 ± 2.8**
6 ± 1.7***
Start arm
26.5 ± 2.9
32 ± 4.1*
38 ± 5.7*
42 ± 5.9**
Other arm
29.5 ± 3.3
38 ± 5.1*
46 ± 6.6**
52 ± 7.8**
*p < 0.05, and **p<0.01. Values represent means ± SD (N=10).
Table 2:
Effect of TiO2 NPs on the spatial recognition memory of mice in Y-maze
after nasal administration of TiO2 NPs for six consecutive months.
