Figure 7: (A) Calcium ionophore (1 μM)-stimulated maximal NO and maximal ONOO- release from isolated brain tissues of rats treated with simvastatin (20 mg·kg-1 daily for 14 days, open bars) or atorvastatin (10 mg·kg-1 daily for 14 days, close bars). Brain slides were obtained after 3 h, 12 h and 24 h of pMCAO. Brain slides were pre-incubated (15 minutes) with L-NAME, 7-NI, VAS2870, sepiapterin or PEG-SOD prior to stimulation of NO and ONOO- release. C is the ratio of maximal NO to maximal ONOO- concentrations of the above corresponding groups. *P< 0.05 vs. vehicle-pre-treated group.