Figure 1: Synthesis pathway to platinum II-based biodegradable polymeric nanoparticle. Poly(AMPD-CAB) having numerous secondary amine group in backbone offers multiple sites for the attachment of various property modifiers. DTPA was attached to poly(AMPD-CAB) by amidation reaction of secondary amine for complexation of cisplatin. The attachments of PEG was achieved by reaction of secondary amines of poly(AMPD-CAB) with 4-nitrophenyl carbonate activated PEG.