|
Code |
Drug amount (mg) |
EC/HPMC
(w/w) |
Temperature (oC) |
Stirring rate (rpm) |
Particle size (μm) |
Yield (%) |
DEE (%) |
Buoyancy (%) |
12 h Cum. release (%) |
| F1 |
300 |
4:1 |
25 |
500 |
944 ± 7.0 |
88.2 ± 3.0 |
98.3 ± 0.9 |
54.1 ± 4.2 |
99.8 ± 5.2 |
| F2 |
700 |
4:1 |
25 |
500 |
1017 ± 16.8 |
89.3 ± 2.1 |
96.5 ± 0.5 |
64.0 ± 3.5 |
62.9 ± 0.4 |
| F3 |
1000 |
4:1 |
25 |
500 |
1092 ± 14.0 |
86.2 ± 3.3 |
93.9 ± 0.8 |
69.1 ± 1.9 |
56.2 ± 1.2 |
| F4 |
300 |
1:1 |
25 |
500 |
718 ± 2.6 |
34.0 ± 2.9 |
86.2 ± 2.4 |
8.1 ± 1.4 |
99.9 ± 3.9 |
| F5 |
300 |
4:1 |
25 |
500 |
944 ± 7.0 |
88.2 ± 3.0 |
98.3 ± 0.9 |
54.1 ± 4.2 |
99.8 ± 5.2 |
| F6 |
300 |
7:1 |
25 |
500 |
1070 ± 6.7 |
89.4 ± 3.6 |
96.0 ± 1.3 |
61.0 ± 2.3 |
47.9 ± 2.2 |
| F7 |
300 |
9:1 |
25 |
500 |
1090 ± 11.5 |
91.1 ± 2.2 |
98.4 ± 1.0 |
77.8 ± 1.9 |
41.3 ± 0.5 |
| F8 |
300 |
4:1 |
20 |
500 |
924 ± 6.1 |
95.4 ± 2.9 |
98.4 ± 1.0 |
50.0 ± 3.8 |
100.9± 0.8 |
| F9 |
300 |
4:1 |
25 |
500 |
944 ± 7.0 |
88.2 ± 3.0 |
98.3 ± 0.9 |
54.1 ± 4.2 |
99.8 ± 5.2 |
| F10 |
300 |
4:1 |
30 |
500 |
976 ± 8.1 |
63.1 ± 3.8 |
86.2 ± 0.6 |
46.1 ± 1.4 |
95.6 ± 2.9 |
| F11 |
300 |
4:1 |
25 |
500 |
944 ± 7.0 |
88.2 ± 3.0 |
98.3 ± 0.9 |
54.1 ± 4.2 |
99.8 ± 5.2 |
| F12 |
300 |
4:1 |
25 |
900 |
791 ± 15.5 |
93.3 ± 1.3 |
97.2 ± 1.1 |
52.2 ± 2.5 |
100.9 ± 1.9 |
| F13 |
300 |
4:1 |
25 |
1200 |
721 ± 9.5 |
91.5 ± 4.2 |
93.2 ± 1.9 |
49.3 ± 1.5 |
99.8 ± 3.4 |
|
