Figure 5: Fenretinide (HPR) concentrations in mice plasma and tumors after administration of HPR-NC3 (E/D = 3) nanocapsules either in feeding or fasting conditions. The mice were inoculated with SK-S-AN neuroblastoma cell lines (5×106 tumor cells/mouse). When the tumors reached a mean volume of 300 mm3 the mice were orally administered at the dose of 100 mg/kg (n=5) once a day. The administrations were carried out 1 day or 5 days either in feeding or fasting conditions. Animals were sacrificed 4 h after the last dose and blood and tumors were collected for determination of their HPR content.