Figure 7: Representative low magnification histological images of critical size defects in sheep after 16 weeks (a) with no implanted material and (b) treated with biomaterial, showing significantly greater bone regeneration of the treated defect when compared to untreated control. Goldner’s trichrome stain shows mineralized bone in blue, collagen fibers present in non-mineralized tissue in red, corresponding to connective tissue outside defect and to non-mineralized organic bone matrix (osteoid) inside defect.