| Figure 5: (A)A172 GBM cells were grafted onto the CAM of a chicken embryoand grown to form tumors. The tumors were then treated topically with IO/HSA control NPs, DOX (2 μg), IO/HSA-TRAIL NPs (50 ng of TRAIL) alone orin combination. (B) U87 GBM cells were grafted onto the CAM of a chickenembryo and grown to form tumors. The tumors were then treated topically withIO/HSA control NPs, DOX (200 ng), IO/HSA-TRAIL NPs (100 ng of TRAIL)alone or in combination. (C) HCT116 colon cancer cells were grafted onto theCAM of a chicken embryo and grown to form tumors. The tumors were thentreated topically with IO/HSA control NPs, DOX (2 μg), IO/HSA-TRAIL NPs (20ng of TRAIL) alone or in combination. Tumor weight was determined for eachtreatment group (n=6, mean ± SD). *, P<0.05; **, P<0.01 from IO/HSA-TRAIL.Abbreviations: w/o treatment, without treatment; IO-TRAIL, IO/HSA-TRAIL;SD, standard deviation. |
