Figure 2: Stability and cytotoxicity.

The release of PTX from RVG-PTX-nanocomplexes was examined by HPLC (A)In contrast to small-size RVG-PTX-nanocomplex (Nanocomplex-S), the larger one (Nanocomlex-L) showed slower controlled release over 786 h, indicating its greater stability. With 72 h treatment at various concentrations, dose dependent cytotoxicity of RVG-PTX-nanocomplex to U87 was detected by MTT assay (B) The size changes and PTX-nanocomplex with or without RVG conjugation did not significantly influenced the cytotoxicity. RVG-PTX-nanocomplex displayed superior efficacy at 0.1 μg/ml