| The specific RVG binding shown in HS-RVG+βME+TRM treated cells
at 2 hrs incubation (A, red signals). No specific binding signals seen in
cultures treated with RVG without functional structure (HS-RVG-TRM) or no
fluorescence labeling (bME-TRM). The untreated TAMs served as control.
RVG binding to AchR mediated RVG-PTX-nanocomplex uptake was analyzed
by immunostaining with antibody to AchR7 (B, green). High levels of AchR
expressed in TAMs, which had taken up RVG-PTX-nanocomplex (B, red) to
display a correlated intracellular distribution (B, merge). |
