Figure 4: Resveratrol incorporated PLGA scaffolds ameliorated inflammatorygenes andupregulated wound healing markers. Gene expression analysis ofM1 macrophages on theresveratrol incorporated scaffolds demonstrated (A)IL-6 expression at days 3 to 7, 14 and 21 post-culture. (B) TNF-α expressionat days 3 to 7, 14 and 21 post-culture. A single asteriskdenotes a significantlyhigher expression of TNF-α at day 3 compared to the previous time point.(C) IL-10 expression at days 3 to 7, 14 and 21 post-culture. (D) VEGFexpression at days 3 to 7, 14 and 21 post-culture. A single asterisk denotes asignificantly higher expression of VEGF at day 21. All experiments were donein triplicate. Data points are plotted as mean ± SD (n=3). A single asteriskdenotes significantly (P ≤ 0.05) higher as compared to groups denoted by twoasterisks. Two asterisks denotes significantly (P ≤ 0.05) higher as comparedto groups denoted by three asterisks. Results demonstrated the highest levelM2 signatory genes in the presence of resveratrol demonstrating the potentialto drive the pro-angiogenic anti-inflammatory response.