(A) Mechanism of release Different CaCl2 concentration, M 0.025 0.05 0.1 0.2 0. 5 1 1st order r - 0.878 - 0.896 - 0.922 - 0.866 - 0.896 - 0.917 K1/min - 0.001 - 0.001 - 0.001 - 0.001 - 0.001 - 0.001 Zero order r 0.834 0.855 0.873 0.838 0.866 0.879 K0, releasepercentage/min 0.157 0.1637 0.154 0.148 0.146 0.144 Higuchi’s diffusion r 0.923 0.938 0.949 0.923 0.943 0.952 Kh, releasepercentage/min 4.048 4.176 3.904 3.799 3.709 3.639 Log Q Vs. log t r 0.952 0.957 0.964 0.959 0.953 0.969 Slope 0.5805 0.448 0.467 0.497 0.536 0.475 Best fitted model kh (B) Mechanism of release Drug:polymer ratios 1:0.5 1:1 1:2 1:3 1:4 1:5 1st order r - 0.899 - 0.972 - 0.922 - 0.936 - 0.922 - 0.814 K1/min - 0.002 -0.001 - 0.001 - 0.001 - 0.001 - 0.001 Zero order r 0.853 0.977 0.873 0.897 0.907 0.805 K0, release percentage/min 0.163 0.088 0.154 0.158 0.0878 0.045 Higuchi’s diffusion r 0.936 0.997 0.949 0.963 0.967 0.901 Kh, release percentage/min 4.211 2.088 3.904 3.951 2.171 1.166 Log Q Vs. log t r 0.981 0.915 0.964 0.981 0.983 0.951 Best fitted model kh

Table 3: Kinetic study of drug release percentage from FLB beads at different CaCl2 concentration and 1:1D: P ratio (A); and Kinetic study of drug release percentage from alginate beads at CaCl2 0.2 M and different D:P ratios in phosphate buffer (25 ± 5°C) (B).