TESTS
Doxil®
PEGADRIA
pH
6.5
6.5
Assay
101.10%
101.40%
Cholesterol
96.10%
96.10%
HSPC
98.30%
98.80%
DSPE-MPEG2000
93.30%
93.20%
Encapsulation Efficiency
97.90%
102.90%
Particle Size (Mean diameter & % Distribution)
67.0 nm45.3 (D10), 64.4 (D50), 91.8 (D90)
61.2 nm45.1 (D10), 59.7 (D50), 79.2 (D90)
Zeta Potential (mV)
-24.89
-25.75
Table 1:
Physicochemical, characterization of PEGADRIA and Doxil®.
