| |
Dose(mg/kg) |
Gender |
Changes in Body Weight(%BW29/BW1) |
| Doxil® |
PEGADRIA |
| Mice(N = 5) |
6 |
Male |
109.6±5.1 |
112.1±7.0 |
| Female |
117.2±3.0 |
116.7±11.9 |
| Rats(N = 6) |
0.5 |
Male |
151.7±6.1 |
146.8±8.1 |
| Female |
140.9±7.7 |
142.2±9.9 |
| 1.0 |
Male |
147.2±6.1 |
137.8±6.5 |
| Female |
137.8±4.5 |
137.2±5.3 |
| 1.5 |
Male |
146.3±3.4 |
134.7±10.9 |
| Female |
136.8±5.5 |
141.6±7.7 |
| %BW29/BW1 = 100 × BW29/BW1.BW1: Body weight on day 1; BW29: Body weight on day 29; Data represent mean ± SD. |
|
