| Drug and formulation |
Dose (mg/kg) x 3, i.p |
MST ( in days) |
T/C (%) |
| Prednisolone |
0.25 |
19.4 |
179.6 |
| |
0.5 |
17.3 |
166.3 |
| |
1.0 |
14.8 |
142.3 |
| |
1.5 |
12.5 |
120.1 |
| Prednisolone loaded PEGylated PPI dendrimer |
0.5 |
20.3 |
195.1 |
| |
1.0 |
21.6 |
207.6 |
| |
2.0 |
23.2 |
223.0 |
| |
4.0 |
26.7 |
256.7 |
| |
8.0 |
28.1 |
270.1 |
| Untreated control |
0 |
10.8 |
- |
MST:Mean Survival Time (days); T:Survival Time of Treated Mice (days);C:Survival Time of Control Mice (days); Significant antileukemic effect at T/C% > 125% was accepted.
Toxic dose at T/C% < 125%. |
|
