Figure 6: BMM facilitate transport of incorporated nanozyme across the BBB toward brain inflammation. 3H-catalase nanozyme loaded into BMM or cell-free nanoparticles were i.t.v. injected in 6-OHDA intoxicated C57BL/6 mice on second (white bars), or seventh (black bars) day after intoxication. Blood and brain samples were taken four hours after the administration, and radioactivity levels were recorded. Results from N=6 mice per group (mean ± SEM) demonstrate significant increase in cell-incorporated nanozyme transport across the BBB in the hemisphere with 6-OHDA injection. No effect in healthy hemisphere was found. Statistical significance is shown by asterisk (*p<0.05, **p<0.005).