Figure 7: Biodistribution of BMM-carried nanozymes in mice with PD model by IVIS. LPS-intoxicated (i.c., 0.5mg/kg) (A), or healthy C57BL/6 mice were i.j.v. injected with Alexa Fluor 680-labeled nanozyme loaded to BMM (5x106cells/mouse). Representative images from N=4 mice per group (dorsal planes) taken at various time points demonstrate prolonged circulation time of nanozyme in the mice with brain inflammation (A) compared to the healthy animals (B). Redistribution of nanozyme from peripheral organs to the brain with inflammation was detected on the second week after adoptive cell transfer in LPS-intoxicated animals (A).