Figure 7: Cardiac ischemia/reperfusion injury following IT instillation of AgNP and AgAc. Cardiac I/R injury in male SD rats exposed to 200 μl of citrate vehicle or 200 μg AgNP or 2-200 μg silver acetate (AgAc) following 20 minutes of ischemia and 2 hours of reperfusion. Ischemia-reperfusion injury is expanded 1 day following IT exposure to AgNP compared to vehicle or naïve (A). Expansion of I/R injury persists 7 days following IT instillation (B). Male SD rats exposed to IT instillation of 0.01 mg/mL (2 µg), 0.1 mg/mL(20 μg), or 1 mg/mL(200 µg) AgAc. I/R injury is expanded 24 hours following IT exposure to the two highest concentrations of AgAc (C). a significant versus naïve, b significant vs vehicle, d vs 1mg/mL AgAc. Data are reported as mean ± SEM with n=3–4.