Source CYP enzymes Substrates Bacterial CYPs CYPBM3 Alkanes (octane to ethane), gaseous alkanes, benzene, propyl benzene, naphthalene  CYPCAM Alkanes (heptane to ethane), halogenated hexanes, PAHs, PCBs, styrene, diphenylmethane, ethylbenzene Mammalian CYPs CYP1A2 Alkoxyresorufin compounds CYP2A6 Indole compounds CYP2B1 7-ethoxytrifluorocoumarin, cyclophosphamide, ifosfamide CYP2B11 7-ethoxytrifluorocoumarin, cyclophosphamide, ifosfamide CYP2Cs 6’-deoxyluciferin, diclofenac   CYP3A4 7-benzyloxytrifluorocoumarin, testosterone

Table 2: Summary of the engineered CYP enzymes for the metabolism of various substrates.