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Scheme 1: Peripheral aerobic pathways of n-alkane degradation. The main pathway is the terminal oxidation to fatty acid. α – and ω – hydroxylation is catalysed by the same set of enzymes. With bacteria, steps 1, 2, 3 are catalysed by alkane monooxygenase, fatty alcohol dehydrogenase and fatty aldehyde dehydrogenase, respectively. With yeast, step 1 is catalysed by P450 monooxygenase, while steps 2 and 3 are catalysed either by fatty alcohol oxidase and fatty aldehyde dehydrogenase, respectively; or by the P450 monooxygenase involved in step 1. |