Cell Type Distribution Action Langerhans/ dendritic cells Abundant in vaginal and cervical mucosa Present antigen to T cells (adaptive); phagocytize bacteria or virus particles (innate) [11] Neutrophils Abundant throughout female genital tract Produce antipathogenic chemokines and cytokines (innate) [50] T cells Abundant within mucosal-associated lymphoreticular tissue within the lamina propria of cervix Direct cytotoxic action(innate) or stimulation of other immune responses (adaptive) [11] CD8+ Most common epithelial T cells in FGT, cytotoxic Kill virus- infected cells (adaptive) [82] CD4+ Less common, Stimulatory Activate macrophages, B cells (adaptive) [82]   NK cells Throughout FGT Kill virus-infected host cells (adaptive and innate mechanisms)[83] Macrophages Abundant within mucosal-associated lymphoreticular tissue within lamina propria of cervix; most abundant phagocytes Present antigen to T cell (adaptive) [11] FGT = female genital tract; NK = natural killer

Table 2: Components of Cell-Mediated Immunity in The Female Lower Reproductive Tract.