Table 3

Skin structure	Enzyme acitvity				Sex steroid receptors
Skin structure	17 β-HSD	3β-HSD	5α-reductase	Aromatase	AR	ERβ	ERα
Epidermal keratinocytes	+ (4- isotypes)		+ (1- isotype)		+	+
Melanocytes					+	+	+
Hair follicles			+ (1- isotype) (2- isotype in beard)
Follicular keratinocytes					+	+
Root sheath	+ (2- isotype)			+		+
Matrix epithelium					+	+
Dermal papilla cells				+	+	+
Sebaceous glands	+ (3- and 5- isotypes)	+ (1- isotype)	+ (1- isotype)	+	+	+	+
Sweat glands			+ (1- isotype)		+
Eccrine						+
Apocrine			+		+	+
Dermal fibroblasts					+	+	+
Endothelial cells					+	+

HSD: Hydroxysteroid dehydrogenase; AR: androgen receptor; ERß: estrogen receptor-beta; ERa: Estorgen receptor-alpha

Table 3: Localization of sex steroidogenic enzymes and androgen and estrogen receptor activity in the skin.