Cofactor

Full Name

Interaction with ER

References

AIB3

Amplified in breast cancer 3

Binds ER AF-2 through LXXLL motifs

[10]

ARNT

Aryl hydrocarbon receptor nuclear translocator

Binds ERa LBD

[11]

BRG-1

Brahma-related gene 1

Binds ERa AF-2 domain

[12]

BCAS2

Breast cancer amplified sequence 2

ND

[13]

CIP1

Clin-dependent kinase inhibitor 1A

ND

[14]

Ciz1

Cip-interacting zinc finger protein 1

Binds ERa DBD

[15]

E6-AP

E6-associated protein

Binds ERa AF-2

[16]

ERIAP

Estrogen Receptor Interacting and Activating Protein

Binds ERa LBD/AF-2

[17].

HER4

Proto-oncogene-like protein c-ErbB-4

Binds ERa AF-1 or AF-2

[18]

hMMS19

 

ND

[19]

ING1b

Inhibitor of growth family, member 1

ND

[20]

IRS-1

Insulin receptor substrate 1

Binds ERa AF-1 or DBD

[21]

LRP16

Leukemia related protein 16

Binds ERa AF-1

[22]

Menin

Multiple endocrine neoplasia type 1

Binds ERa AF-2

[23]

MICoA

MTA1-interacting coactivator

Binds ERa AF-2 through LXXLL motifs

[24]

MUC1

mucin 1, cell surface associated

Binds ERa DBD

[25]

Pak1

p21-activated kinase 1

Binds ERa AF-1 or AF-2

[26]

PELP1

proline-,glutamic acid-,and leucine-rich protein-1

Binds ERa AF-2 through LXXLL motifs

[27]

p68

p68 RNA helicase

Binds ERa AF-1

[28]

p300

Histone acetyltransferase p300

Binds ERa AF-2 through LXXLL motifs

[29]

SIRT1

sirtuin 1

ND

[30]

SRC1

Steroid receptor coactivator 1

Binds ERa AF-2 through LXXLL motifs

[31]

SRC-3

Steroid receptor coactivator-3

Binds ERa AF-2 through LXXLL motifs

[32]

SRA

Steroid receptor RNA activator

Binds ERa AF-1

[33]

TIF1

Transcriptional intermediary factor 1

Binds ERa AF2 domain

[34]

TIF2

Transcriptional intermediary factor 2

Binds ERa AF-2 through LXXLL motifs

[35]

TRAP220

Thyroid hormone receptor activating protein of 220 kDa

Binds ER AF-2 through LXXLL motifs

[36]

XBP-1

X-box binding Protein l

Binds ERa DBD

[37]

Table 1: Estrogen receptor cofactors.