Protein functional biological theme Number of proteins changing Trend of protein expression in pregnancy Protein kinase activity 2 Up regulated Proliferation 9 Up regulated Calcium binding 3 Up regulated Tissue remodeling 4 Down regulated Circulation 3 Down regulated Immune-related proteins 11 Up regulated Nucleus-related proteins 3 Up regulated Cellular adhesion 3 Up regulated Cytoskeleton-related proteins 17 Up regulated Carbohydrate metabolism 3 Down regulated Extracellular matrix 6 Up regulated Heat shock proteins 1 Up regulated

Table 2: The biological themes are variably expressed in mice cervix during pregnancy (early and late) and in non-pregnant mice. Proteins were assigned to these groups based on function.