Hormones Main effect Consequence Therapeutical implication for NP Prostaglandins: PGE2 PGI2 → antagonizes ADH → antagonizes RAAS Diuresis NSAIDs Melatonin stimulates ADH stimulates RAAS Antidiuresis Melatonin Sex hormones: estrogens progesterone testosterone → stimulates ADH, Renin, Ang II, ANP; inhibits Aldosteron → stimulates Aldosteron; antagonizes ADH, ANP → stimulates ADH, Renin, Ang II Antidiuresis Replacement therapy if necessary PGE2: Prostaglandin E2; PGI2: Prostaglandin I2; ADH: Antidiuretic Hormone; RAAS: Renin-Angiotensin-Aldosterone System; ANP: Atrial Natriuretic Peptide; NSAIDs: Non-Steroidal Anti-Inflammatory Drugs

Table 2: Influence of prostaglandins, melatonin and sex hormones on the antidiuretic and diuretic hormones