Figure 1: 5-HT2A receptor binding sites detected with [3H]-MDL100907 in prefrontal cortex (PFC) were significantly decreased 15% 8 days after ovariectomy (OVX) (71.4 ± 3.4 fmol/mg tissue equivalents (TE)) relative to shamOVX (82.19 ± 1.5 fmol/mg TE) (Panel A). 23 days after OVX, [3H]-MDL100907 binding was decreased 13.5% with borderline significance (45.7 ± 1.6 fmol/mg TE) relative to shamOVX (51.89 ± 2.0 fmol/mg TE) (Panel B). (C) Representative autoradiograms of 8 days shamOVX and OVX. The bars represent mean ± SEM (day 8: n=5/6 and day 23: n=4/4), *P<0.05 using Students t-test.