Figure 2: SERT binding sites detected with [3H]-escitalopram in prefrontal cortex (PFC) were unchanged 8 days (Panel A) and 23 days (Panel B) after ovariectomy (OVX) (80.2 ± 3.5 fmol/mg tissue equivalents (TE) and 24.7 ± 2.2 fmol/mg TE respectively) compared to shamOVX groups (78.0 ± 3.1 fmol/mg TE and 28.4 ± 1.4 fmol/mg TE respectively). In striatum, SERT binding was unchanged 8 days after OVX (68.4 ± 2.2 fmol/mg TE) compared to shamOVX (66.1 ± 1.8 fmol/mg TE) (Panel C) and 23 days after OVX (16.5 ± 1.4 fmol/mg TE) relative to shamOVX (19.4 ± 0.5 fmol/mg TE) (Panel D). The bars represent mean ± SEM (day 8: n=6/6 and day 23: n=4/4), P=0.09 using Students t-test.