Figure 4: Wheel running indices (distance, duration, and speed) for male C57BL/6J mice at baseline, during injections, during steroid replacement, and during steroid replacement with injections. White bars denote control mice (n=10) that received vehicle injections and empty silastic implants. Checkered bars denote experimentally treated mice (n=10) that received silastic implants containing testosterone and exemestane injections. Black bars denote experimentally treated mice (n=10) that received silastic implants containing 17-estradiol and exemestane injections. *=significantly different from controls and baseline values.