Table 1

[ASP]/µM	q / µ J (o)	q_dilut /µ J (o)	q / µ J (∆)	q_dilut /µ J (∆)
7.0	-125.3	-18.4	-94.9	-18.4
10.5	-125.5	-15.6	-95.7	-15.6
13.9	-125.8	-13.5	-95.9	-13.5
17.2	-125.8	-11.5	-96.7	-11.5
20.5	-125.4	-10.3	-95.5	-10.3
23.8	-123.9	-9.4	-93.2	-9.4
27.0	-120.5	-6.9	-85.8	-6.9
30.2	-113.2	-6.1	-76.5	-6.1
33.3	-108.0	-4.9	-74.1	-4.9
36.4	-105.0	-4.2	-74.7	-4.2
39.4	-104.8	-2.7	-77.0	-2.7
42.5	-105.1	-1.9	-79.2	-1.9
45.4	-104.8	-0.6	-80.7	-0.6
48.4	-104.9	0.3	-82.2	0.3
51.2	-105.2	1.7	-83.2	1.7
54.1	-105.4	2.6	-83.9	2.6
56.9	-105.7	3.3	-83.8	3.3
59.7	-105.1	3.4	-84.0	3.4
62.5	-103.0	3.4	-83.3	3.4
65.2	-101.4	2.9	-82.0	2.9
67.9	-100.8	4.3	-82.2	4.3
70.5	-98.9	4.1	-81.3	4.1
73.1	-97.2	3.2	-79.9	3.2
75.7	-95.5	2.9	-78.9	2.9
78.3	-94.8	3.9	-78.8	3.9
80.8	-92.0	3.5	-78.1	3.5
83.3	-87.7	1.9	-74.2	1.9

Table1: Heats of aspirin+HSA interactions, q, at 298 K (o) and 310 K (Δ) in H₂O solution of pH=7. q_dilut are the heats of dilution of aspirin with water. The precision
is ±0.1 μJ or better.