Wuji Wan Formulae Decomposition IC50of Formula/μg(crude drug) •mL-1 Formula IC50
A: HL B: WZY C: BS
single HLextract 251.17 ± 33.90 - - 251.17 ± 33.90
single WZYextract - 1925.82 ± 241.66 - 1925.82 ± 241.66
single BS extract - - 2.18e+09 ± 5.3e+09 2.18e+09 ± 5.3e+09
1#F extract 315.39 ± 41.06 1) 105.13 ± 13.68*) 315.39 ± 41.06Ⅲ) 735.93 ± 95.82
2#F extract 103.86 ± 3.47 3) 69.24 ± 2.31*) 207.73 ± 6.94Ⅲ) 380.84 ± 12.74
3#F extract 181.61 ± 9.38 2) 363.23 ± 18.77*) 726.46 ± 37.54Ⅲ) 1271.31 ± 65.69
4#F extract 135.44 ± 6.08 3) 22.57 ± 1.01*) 135.44 ± 6.08Ⅲ) 293.46 ± 13.18
5#F extract 147.21 ± 15.89 3) 49.07 ± 5.29*) 294.42 ± 31.78Ⅲ) 490.71 ± 52.97
6#F extract 113.32 ± 16.66 3) 113.32 ± 16.66*) 56.66 ± 8.33Ⅲ) 283.30 ± 41.65
7#F extract 286.09 ± 38.19 23.84 ± 3.18*) 286.09 ± 38.19Ⅲ) 596.02 ± 79.57
8#F extract 161.38 ± 21.42 3) 26.89 ± 3.57*) 40.34 ± 5.35Ⅲ) 228.63 ± 30.34
9#F extract 211.33 ± 21.55 1) 105.67 ± 10.78*) 105.67 ± 10.78Ⅲ) 422.68 ± 43.12
Note: (1) the decomposition IC50 was calculated by table 1 ratios;
(2) compared with the IC50 of HL,1)P<0.05, 2)P<0.01, 3)P<0.001; compared with the IC50 of WZY, *)P<0.001; compared with the IC50 of BS,Ⅲ)P<0.001.
Table 3b: The IC50 values of Wuji Wan on the activities of CYP2A6 ( , n=6) (continue 2).