Wuji Wan Formulae Decomposition IC50of Formula/μg(crude drug) •mL-1 Formula IC50
A: HL B: WZY C: BS
single HLextract 343.37 ± 69.09 - - 343.37 ± 69.09
single WZY extract - 1713.23 ± 464.29 - 1713.23 ± 464.29
single BSextract - - 20137.80 ± 14938.56 20137.80 ± 14938.56
1#F extract 339.31 ± 35.32 113.10 ± 11.77*) 339.31 ± 35.32Ⅲ) 791.73 ± 82.42
2#F extract 240.80 ± 15.92 1 160.53 ± 10.61*) 481.61 ± 31.85Ⅲ) 882.96 ± 58.40
3#F extract 245.52 ± 32.93 1) 491.04 ± 65.87*) 982.09 ± 131.75Ⅲ) 1718.66 ± 230.56
4#F extract 136.59 ± 11.31 3) 22.76 ± 1.88*) 136.59 ± 11.31Ⅲ) 295.95 ± 24.51
5#F extract 192.45 ± 15.82 2) 64.15 ± 5.27*) 384.90 ± 31.65Ⅲ) 641.50 ± 52.76
6#F extract 277.41 ± 143.49 277.41 ± 143.49*) 138.70 ± 71.74Ⅲ) 693.54 ± 358.72
7#F extract 174.95 ± 19.472) 14.57 ± 1.62*) 174.95 ± 19.47Ⅲ) 364.49 ± 40.57
8#F extract 128.18 ± 23.59 3) 21.36 ± 3.93*) 32.04 ± 5.89Ⅲ) 181.59 ± 33.43
9#F extract 133.19 ± 29.24 3) 66.59 ± 14.62*) 66.59 ± 14.62Ⅲ) 266.39 ± 58.48
Note: (1) the decomposition IC50 was calculated by table 1 ratios;
(2) compared with the IC50 of HL,1P<0.05, 2)P<0.01, 3)P<0.001; compared with the IC50 of WZY, *)P<0.001; compared with the IC50 of BS,Ⅲ)P<0.001.
Table 3c: The IC50 values of Wuji Wan on the activities of CYP2C19 ( , n=6) (continue 3).